Technology
Biomillenia has unique expertise in isolating microorganisms, including rare and previously uncultured species. Our robust microfluidic workflows have been already validated with source materials such as animal feces (wild, domestic and farmed species), human samples (feces, skin, mouth…), agriculture (soil, leaves, roots…) and environmental materials.
After extraction, microorganisms are isolated in monoclonal cultures using tens of millions of microscopic bioreactors. This allows parallelization of bacterial growth between individually isolated microorganisms in extremely small volumes. These cultures can be generated and maintained under aerobic or anaerobic conditions. Other culturomic factors such as incubation time, choice of medium or temperature are also adjusted to achieve optimal growth. This unique culture environment significantly improves the diversity of the cultured microbiota compared to traditional culture methods, resulting in strain collections containing a wide range of bacterial strains from the original sample.
Our approach not only shortens the overall duration of strain bank operation, but also allows us to deliver high-quality cell libraries with:
Guaranteed monoclonality of cultures
Flexible strain identification:
Traceability from sample to microorganism
Delivery of “Master cell bank ready” cryotubes or MTP
All our collections come with a free one month strain-bank backup
Read our white paper.
Real case studies
To enable the discovery of new natural small molecules from the human microbiome, Design Pharmaceuticals needed to access new gut strains grown under stringent anaerobic conditions. The unique strains captured in our microfluidic system showed interesting GPCR activation profiles.
A major international player* in animal care needed to isolate bacterial strains from different breeds of pets to identify next-generation probiotic strains for animal care. Samples from pets living in different environments were processed with traceability from isolate to original sample to better understand differences between pets living in urban and rural environment.
*[undisclosed for confidentiality reasons]