Mutagenesis and directed evolution


The final yield of a bioprocess is directly linked to the efficiency of the strain used. Biomillenia’s ultra-high-throughput screening platform, in synergy with digital culturomics, enables best-in-class directed evolution. Following mutagenesis, the identification and selection of organisms is performed at a speed and scale unmatched by any other platform. While strains for bioproduction are typically selected from thousands of mutants, we start from millions, which increases the ability to find most productive candidate strains many times over!

Special microfluidic chips can be developed to perform these types of assays. Here is an example of the microfluidic workflow of a yeast-based process:

workflow figure
Figure source: Scientific Reports | 6:27223 | DOI: 10.1038/srep27223

Beside directed evolution, these ultra-high-throughput capabilities can be used as well for the selection of natural strains, for more information click here.

Real case studies

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