Ultra High-Throughput Assays on Live Microorganisms
Droplet making with Yeast cells
This video is very slow motion (300x slower): our unique technology allows us to generate 30 million droplets per hour! If you need to think big in your microbiological assays, microfluidics is made for you.
Microfluidic droplets generated by nozzles
Another technique of generating droplets is based on nozzles. They allow the generation of droplets of exactly identical size, increasing overall assay robustness. Nozzles can generate “only” 40 droplets per second, nevertheless, by using multiple nozzles in parallel the throughput becomes massive!
Filamentous fungi in droplets
Droplets are not only suitable for bacteria: this video shows filamentous fungi developing very nicely inside the droplets.
Our platform is the result of our unique knowledge in microfluidics, combined with our deep knowledge of culturomics: we can adapt cultivation conditions exquisitely to the microorganisms under investigation. We can even grow microalgae!
Once generated, each one of those droplets is ready to serve as a lab bench bioreactor.
Thanks to our patented technologies, Biomillenia can interact with the droplets and design and implement microbiological essays, at very high throughput: this is a slow-motion video; actual droplet flow is more than 200 times faster!
Inhibition assays require the co-culture of organisms Then a good option is to generate a first set of droplets with the agonist and a second one with the anti-agonist (eg: microbes extracted from a microbiome sample), incubate them separately and then merge the 2 sets of droplets.
Using microfluidics, we can generate 2000 co-cultures per second!